Arrangementer på Institut for Kemi og Biovidenskab

PhD Defense by Søren Sejer Donau

Søren Sejer Donau, Department of Chemistry and Bioscience will defend his thesis on: "Investigation of fundamental properties of novel 3-amino-2cyano-2-phenylacrylate fungicides and de-rivatives - structures, synthesis and degradation"

Tidspunkt

06.04.2018 kl. 09.30 - 06.04.2018 kl. 12.30

Beskrivelse

TITLE:

"Investigation of fundamental properties of novel 3-amino-2cyano-2-phenylacrylate fungicides and derivatives - structures, synthesis and degradation"

ABSTRACT:

More than a century has passed since the first synthesis of the compound: ethyl 3-amino-2-cyano-3-phenyl acrylate, later known under the develop code; JS399-19 and the commercial name; Phenamacril. However, it is within the last two decades that the compound has gotten much attention due to the discovery of its anti-fungal properties. The compound has showed a high specificity and activity against specific genus of Fusarium, making it a strong candidate for controlling infection in crops caused by Fusarium. In 2015, the compound was revealed as a myosin inhibitor. Myosin inhibitors (or activators) are of great scientific interest, especially in the development of new drug candidates, thus further increasing the interest in Phenamacril and its derivatives.

Despite the long-term acquaintance of the compound, literature seems to lack knowledge regarding several aspects of Phenamacril.

Surprisingly, the stereochemical configuration of the compound remained uncovered even a century after its first appearance and recent literature seems to omit or misrepresent the stereochemical configuration. Consequently, a large degree of discrepancy and confusion regarding the structure of the compound exists.

As a fungicide, environmental effects of the compound, including degradation of the compound in several environmental settings, are of high importance. However, while the compound is often stated as “safe”, information upon toxicity and environmental effects and behavior has only been published sparely.

This thesis has primarily illuminated three topics related to Phenamacril and its derivatives; i) synthesis, ii) structure and iii) degradation in sludge, biofilm and soil.

SUPERVISOR:

  • Professor MSO Reinhard Wimmer

ASSESSMENT COMMITTEE:

  • Associate Professor Donghong Yu (Chairman), Department of Chemistry and Bioscience, AAU, Denmark
  • Associate. Professor. Wolfgang Schöfberger, Institute of Organic Chemistry, Johannes-Kepler-University Linz, Austria 
  • Professor Kurt Gothelf, Department of Chemistry, Aarhus University, Denmark

AFTER THE DEFENSE A SMALL RECEPTION WILL BE HELD AT FREDRIK BAJERS VEJ 7H. 

Pris

Free

Arrangør

Department of Chemistry and Bioscience, AAU, Section of Biotechnology

Adresse

Fredrik Bajers Vej 7H, 9220 Aalborg Ø, room number: 3.122-8