Fredrik Bajers Vej 5
Postboks 159 9100 Aalborg
Telefon: 9940 9940
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Søren Sejer Donau, Department of Chemistry and Bioscience will defend his thesis on: "Investigation of fundamental properties of novel 3-amino-2cyano-2-phenylacrylate fungicides and de-rivatives - structures, synthesis and degradation"
06.04.2018 kl. 09.30 - 06.04.2018 kl. 12.30
"Investigation of fundamental properties of novel 3-amino-2cyano-2-phenylacrylate fungicides and derivatives - structures, synthesis and degradation"
More than a century has passed since the first synthesis of the compound: ethyl 3-amino-2-cyano-3-phenyl acrylate, later known under the develop code; JS399-19 and the commercial name; Phenamacril. However, it is within the last two decades that the compound has gotten much attention due to the discovery of its anti-fungal properties. The compound has showed a high specificity and activity against specific genus of Fusarium, making it a strong candidate for controlling infection in crops caused by Fusarium. In 2015, the compound was revealed as a myosin inhibitor. Myosin inhibitors (or activators) are of great scientific interest, especially in the development of new drug candidates, thus further increasing the interest in Phenamacril and its derivatives.
Despite the long-term acquaintance of the compound, literature seems to lack knowledge regarding several aspects of Phenamacril.
Surprisingly, the stereochemical configuration of the compound remained uncovered even a century after its first appearance and recent literature seems to omit or misrepresent the stereochemical configuration. Consequently, a large degree of discrepancy and confusion regarding the structure of the compound exists.
As a fungicide, environmental effects of the compound, including degradation of the compound in several environmental settings, are of high importance. However, while the compound is often stated as “safe”, information upon toxicity and environmental effects and behavior has only been published sparely.
This thesis has primarily illuminated three topics related to Phenamacril and its derivatives; i) synthesis, ii) structure and iii) degradation in sludge, biofilm and soil.
Department of Chemistry and Bioscience, AAU, Section of Biotechnology
Fredrik Bajers Vej 7H, 9220 Aalborg Ø, room number: 3.122-8
20.03.2018 kl. 10.00 - 20.03.2018 kl. 12.00
Dr. Karen Ocorr fra SBP Medical Discovery Institute, San Diego will give a lecture entitled: From Arrhythmias to Space Travel – Insights from the Fly Heart.
09.04.2018 kl. 14.00 - 09.04.2018 kl. 15.30
Michael Toft Overgaard tiltrådte den 1. marts 2018 som institutleder for Institut for Kemi og Biovidenskab på Aalborg Universitet.
29.08.2018 kl. 17.00 - 31.08.2018 kl. 16.00
The 17th Nordic Filtration Symposium will be organized by The Nordic Filtration Society and Aalborg University, Denmark. The focus of the symposium is separation processes for resource recycling but other topic regarding filtration and separation are welcome. There will be oral sessions and poster exhibitions.